In Create React App, you can include polyfills to support older browsers by using the "core-js" library, the "@babel/preset-env" package, or the "react-app-polyfill" package. These packages provide polyfills for various ES6+ features and browser APIs, and can be configured in the "babel.config.js" or "webpack.config.js" files.

React has several advantages, including improved performance, reusable components, and good community support. React's use of a virtual DOM and its focus on component-based architecture help improve performance and make it easier to develop complex UI components. React's component-based architecture also makes it easier to create reusable components that can be used across multiple projects. React has a large and active community of developers, which provides good support and resources for learning and development.

Keyed Fragments are a feature in React that allows elements to be grouped together without adding extra nodes to the DOM. This can improve performance and reduce the complexity of the component hierarchy. Keyed Fragments are created by using the element and adding a unique key prop to each child element.

Relay is a library for managing network requests in React applications. It is often used in conjunction with GraphQL APIs and provides a number of features for managing data fetching and caching, such as automatic batching, optimistic updates, and pagination. Relay also provides a way to declare data dependencies for your components, which can help to reduce unnecessary re-renders.

React Mixins are reusable code snippets that can be applied to multiple components in order to provide shared functionality. They are a way to encapsulate logic and behavior that can be used across multiple components, allowing for code reuse and reducing duplication. However, they are not recommended in modern versions of React and have been largely replaced by higher-order components and render props.

Loadable components are a way to load other components asynchronously in React. Loadable components allow components to be split into smaller chunks and loaded on-demand, improving performance and reducing initial load times. Loadable components are typically used with dynamic imports to enable asynchronous loading of code.

Higher-Order components (HOCs) are components that enhance the behavior of other components by adding additional functionality or props. HOCs take a component as input and return a new component that includes the additional behavior. This allows developers to reuse code and separate concerns in their applications.

redux-saga is a middleware library for Redux that allows you to handle side effects, such as asynchronous data fetching or complex state updates, in a declarative and testable way. It uses ES6 Generators to provide a more readable and maintainable way to handle complex logic in your Redux application.

Forward refs are a way to pass a ref from a parent component to a child component. This allows the parent component to access and manipulate the child component's DOM node. Forward refs are created using the React.forwardRef() function.

It is not mandatory to define a constructor for a React component. If the component does not need to set its initial state or bind methods to the component, the constructor can be omitted. Additionally, if the component does not have any props, a constructor is not necessary.