In large applications, frequent change detection cycles can lead to performance issues, especially if the application does not use the ________ change detection strategy.

In large Angular applications, frequent change detection cycles can indeed lead to performance issues. By default, Angular uses the Default change detection strategy, which checks all components in each cycle. To address this, developers can use the ChangeDetectionStrategy.OnPush strategy, which limits change detection to components that receive input changes or manually trigger detection, significantly improving performance for large applications.